INFLUENCE OF LEAD ACETATE ON LIPID PEROXIDATION IN THE PROCESS OF LIVER MITOCHONDRIAL MEMBRANE AND ITS CORRECTION WITH DHQ-11 CONJUGAT

Authors

  • Ernazarov Z. M., Pozilov M. K., Jurakulov Sh. N. Institute of Biophysics and Biochemistry under the National University of Uzbekistan, Tashkent city. Institute of Chemistry of Plant Substances named after Academic S. Yu. Yunusov, Tashkent city.

Abstract

Mitochondria placed in the cell are targets for heavy metals. Among them, Pb2+ ions have a negative impact on the functional system of mitochondria[4,5]. Under the influence of heavy metals, there is a violation of electron transport in the mitochondrial respiratory chain and an increase in the amount of ROS. Damage to the mitochondrial membrane caused by heavy metals can be repaired with plant substances. However, the effect of the DHQ-11 conjugate [3] based on the flavonoid dihydroquercetin separated from the Siberian cedar and the isoquinoline alkaloid F-18 on LPO induced by Pb2+, Fe2+ and ADP in the liver mitochondrial membrane has not been investigated in vitro [4].

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Published

2023-03-01

Issue

2023: 11th ICRHASE: Germany Feb

Section

Articles

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

INFLUENCE OF LEAD ACETATE ON LIPID PEROXIDATION IN THE PROCESS OF LIVER MITOCHONDRIAL MEMBRANE AND ITS CORRECTION WITH DHQ-11 CONJUGAT. (2023). Conferencea , 145-149. https://conferencea.org/index.php/conferences/article/view/2143