FEATURES OF THE COURSE OF SEVERE FORMS OF COVID-19 DEPENDING ON THE IMMUNOPHENOTYPE OF PATIENTS

Abstract

The COVID-19 pandemic caused by SARS-CoV-2 has become a serious threat to humanity, affecting almost all of humanity on earth, resulting in the death of more than 10 million people [1] worldwide. Intense inflammation, manifested by increased levels of cytokines, commonly referred to as “cytokine storm”, often leads to critical conditions such as ARDS (acute respiratory distress syndrome) and death due to multiple organ failure [2,4,5,15,16] .
The innate immune response is the first step in the defense mechanism against viral infection. Pattern recognition receptors in host dendritic cells recognize viral genomic DNA or RNA to initiate the production of cytokines and chemokines [3,6,7,9,11,12,16,24], which in turn attract immune cells such as macrophages, neutrophils and T cells, to the site of infection depending on their source and target cells [2,6,7,14].