EFFECT OF POLYPHENOLS ON Fe2+/CITRATE-INDUCED MITOCHONDRIAL VOLUME CHANGE IN TETRACHLOROMETHANE-INDUCED TOXIC HEPATITIS
2023, Articles
2023

EFFECT OF POLYPHENOLS ON Fe2+/CITRATE-INDUCED MITOCHONDRIAL VOLUME CHANGE IN TETRACHLOROMETHANE-INDUCED TOXIC HEPATITIS

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Published 2023-10-08
Turdieva O. M
Kokan State Pedagogical University, Kokand city Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent
Abdulladjanova N.G
Makhmudov R.R
Pozilov M.K
Kokan State Pedagogical University, Kokand city Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent National University of Uzbekistan named after M.Ulugbek, Tashkent
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Turdieva O. M, Abdulladjanova N.G, Makhmudov R.R, & Pozilov M.K. (2023). EFFECT OF POLYPHENOLS ON Fe2+/CITRATE-INDUCED MITOCHONDRIAL VOLUME CHANGE IN TETRACHLOROMETHANE-INDUCED TOXIC HEPATITIS. Conferencea, 11–13. Retrieved from https://conferencea.org/index.php/conferences/article/view/2876
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Abstract

Formation of H2O2 free radicals as a result of lipid peroxide oxidation (LPO) in the membrane is of great importance in pathological processes. Increased production of free radicals in the mitochondrial respiratory complex weakens the antioxidant defense system and damages membrane lipoprotein components. In toxic hepatitis caused by tetrachloromethane (CCl4) and many other pathologies, the intensity of LPO increases based on the development of oxidative stress. In conditions of CCl4-induced toxic hepatitis, biologically active substances are widely used to reduce membrane LPO [1; 2].

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