EFFECT OF POLYPHENOLS ON Fe2+/CITRATE-INDUCED MITOCHONDRIAL VOLUME CHANGE IN TETRACHLOROMETHANE-INDUCED TOXIC HEPATITIS

Authors

  • Turdieva O. M Kokan State Pedagogical University, Kokand city Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent
  • Abdulladjanova N.G
  • Makhmudov R.R
  • Pozilov M.K Kokan State Pedagogical University, Kokand city Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent National University of Uzbekistan named after M.Ulugbek, Tashkent

Abstract

Formation of H2O2 free radicals as a result of lipid peroxide oxidation (LPO) in the membrane is of great importance in pathological processes. Increased production of free radicals in the mitochondrial respiratory complex weakens the antioxidant defense system and damages membrane lipoprotein components. In toxic hepatitis caused by tetrachloromethane (CCl4) and many other pathologies, the intensity of LPO increases based on the development of oxidative stress. In conditions of CCl4-induced toxic hepatitis, biologically active substances are widely used to reduce membrane LPO [1; 2].

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Published

2023-10-08

Issue

2023: 19th Tech-Fest: Germany October

Section

Articles

License

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

EFFECT OF POLYPHENOLS ON Fe2+/CITRATE-INDUCED MITOCHONDRIAL VOLUME CHANGE IN TETRACHLOROMETHANE-INDUCED TOXIC HEPATITIS. (2023). Conferencea , 11-13. https://conferencea.org/index.php/conferences/article/view/2876